Tetrodotoxin, Epinephrine, and Chemical Permeation Enhancer Combinations in Peripheral Nerve Blockade
نویسندگان
چکیده
منابع مشابه
Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia
Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, combinations of tetrodotoxin (TTX) with bupivacaine had supra-additive effects on sciatic block durations. In those studies, epinephrine combined with TTX prolonged blocks mor...
متن کاملPeripheral Nerve Blockade
1Department of Anaesthesiology and Intensive Care Medicine, Semmelweis University, Kutvolgyi ut 4, 1125 Budapest, Hungary 2Department of Anaesthesia and Intensive Care Medicine, Lapeyronie Hospital, Montpellier, France 3Department of Anesthesiology and Pain Medicine, Western Memorial Regional Hospital, 1 Brookfield Avenue, Corner Brook, NL, Canada A2H 6J7 4Department of Anaesthesia and Intensiv...
متن کاملC-fiber-Selective Peripheral Nerve Blockade
Despite the clinical demand, current uses of local anesthetics do not allow selective blockade of nociceptive fibers. Regional anesthesia produces an analgesic effect accompanied with undesired side effects due to block of motor, non-nociceptive sensory and autonomic fibers. These side effects limit the clinical use of local anesthetics and affect the recovery and rehabilitation period after su...
متن کاملAntiinflammatory effect of peripheral nerve blockade.
To the Editor:—We read with interest Martin et al.’s study on the antiinflammatory effect of peripheral nerve block after total knee arthroplasty. We would be delighted to see such an outcome; however, we wish to raise the following questions on the conclusion drawn that peripheral nerve blocks have a clinical antiinflammatory effect, especially when there was no change in inflammatory mediator...
متن کاملComplications of regional anesthesia: nerve injury and peripheral neural blockade.
Nerve injuries have been described as clinical, anatomic, or laboratory findings, consistent with damage to discrete elements of the peripheral nervous system. This rather broad definition of nerve injury has several important implications. For example, a patient may develop a subjective sensory or motor deficit (“clinical findings”) although there are no laboratory tests or studies that confir...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2017
ISSN: 0003-2999
DOI: 10.1213/ane.0000000000002072